Intracytoplasmic sperm injection (ICSI)

Published on: 2026-05-19 | Written by: Dr. Basem Doss, Consultant Obstetrician


ICSI (Intracytoplasmic Sperm Injection) is considered one of the most advanced and important assisted reproductive technologies that has helped thousands of couples achieve their dream of parenthood, especially in cases where natural pregnancy is difficult. With major advancements in fertility treatments, success rates have significantly improved thanks to accurate diagnosis and continuous medical follow-up. Dr. Bassem Dos emphasizes that ICSI has become an effective and safe solution for many causes of infertility in both men and women.


What Is ICSI?

ICSI is an assisted reproductive technique in which a single sperm is directly injected into an egg inside a laboratory to increase the chances of fertilization. After fertilization occurs, the resulting embryos are transferred into the uterus.

Dr. Bassem Dos explains that this technique differs from natural conception and other fertility treatments, as it helps overcome many infertility issues that may prevent fertilization naturally.


When Is ICSI Recommended?

There are several situations in which ICSI may be recommended, including:

  • Severe low sperm count
  • Poor sperm motility
  • Abnormal sperm morphology
  • Blocked fallopian tubes in women
  • Endometriosis
  • Unexplained infertility
  • Previous unsuccessful pregnancy attempts

Dr. Bassem Dos points out that the decision to proceed with ICSI is not based solely on delayed pregnancy, but requires a detailed medical evaluation of both partners.


Steps of the ICSI Procedure

ICSI involves several important stages, including:

1. Ovarian Stimulation

The wife is given medications to stimulate the ovaries and produce multiple eggs instead of just one.

2. Egg Retrieval

The eggs are collected through a simple medical procedure under professional supervision.

3. Sperm Preparation

The highest-quality sperm with the best movement and shape are selected.

4. Fertilization in the Laboratory

A single sperm is injected directly into the egg using precise laboratory techniques.

5. Embryo Transfer

After embryo development, the healthiest embryos are selected and transferred into the uterus.

Dr. Bassem Dos confirms that following medical instructions carefully throughout every stage increases the likelihood of success.


Success Rate of ICSI

The success rate of ICSI depends on several factors, including:

  • The woman’s age
  • Egg and sperm quality
  • Cause of infertility
  • Experience of the medical team
  • Lifestyle and overall health

Dr. Bassem Dos emphasizes that success does not rely solely on the procedure itself, but also on proper diagnosis and close monitoring before and after treatment.


Important Tips Before ICSI

To improve success rates, it is recommended to:

  • Follow a healthy diet
  • Quit smoking
  • Reduce stress and anxiety
  • Adhere to prescribed medications and medical instructions
  • Maintain a healthy weight

Dr. Bassem Dos strongly stresses the importance of emotional support for couples during the treatment journey, as mental well-being may indirectly influence outcomes.


Is ICSI Safe?

ICSI is considered a safe medical procedure when performed in specialized fertility centers under professional supervision. Complications are usually minimal and can often be managed effectively.

Dr. Bassem Dos confirms that medical advancements have significantly improved both safety and success rates while reducing associated risks.


Reasons for ICSI Failure

In some cases, the first attempt may not succeed due to factors such as:

  • Poor embryo quality
  • Uterine lining problems
  • Genetic or hormonal issues
  • Inadequate response to treatment

Dr. Bassem Dos explains that failure in the first attempt does not mean future success is impossible; sometimes, treatment plans simply need adjustment.


ICSI has become one of the most important modern medical solutions for infertility treatment and has helped many couples achieve pregnancy after years of waiting. Dr. Bassem Dos emphasizes that the success of the procedure depends on accurate diagnosis, choosing the right timing, following the treatment plan carefully, and maintaining continuous follow-up with a specialist to maximize the chances of a healthy and safe pregnancy.

دكتور أسنان فى اسكندريةدكتور نساء وتوليد فى اسكندريةدكتور عيون فى الاسكندريةدكتور نفسية وعصبية فى الاسكندريةدكتور أنف وأذن وحنجرة فى الاسكندريةدكتور طب طبيعى وروماتيزممستشفياتصيدلياتمعامل تحاليلدليلي ميديكالدكتور باطنة في الاسكندريةدكتور جراحة عامة في الاسكندريةدكتور تجميل في الاسكندريةدكتور اوعية دموية في الاسكندريةدكتور أطفال فى إسكندريةدكتور عظام فى إسكندريةدكتور أوعية دموية فى إسكندريةدكتور جهاز هضمى وكبد فى إسكندريةدكتور مسالك بولية فى إسكندريةدكتور قلب فى إسكندريةدكتور جلدية فى إسكندريةدكتور تغذية علاجية فى إسكندريةدكتور حساسية وصدر فى إسكندريةدكتور مخ وأعصاب فى إسكندريةدكتور أورام فى إسكندريةدكتور أسنان بالقاهرةدكتور أطفال بالقاهرةدكتور أنف وأذن وحنجرة بالقاهرةدكتور قلب بالقاهرةدكتور باطنة بالقاهرةدكتور تخاطب بالقاهرةدكتور جراحة أطفال بالقاهرةدكتور أورام بالقاهرةدكتور أوعية دموية بالقاهرةدكتور أمراض دم بالقاهرةدكتور جهاز هضمى وكبد بالقاهرةدكتور حساسية وصدر بالقاهرةدكتور تغذية علاجية بالقاهرةدكتور جراحة تجميل بالقاهرةدكتور جراحة عامة بالقاهرةدكتور جلدية بالقاهرةصيدليات بالقاهرةدكتور نساء وتوليد فى القاهرةدكتور مسالك بولية فى القاهرةدكتور طب طبيعي وروماتيزم بالقاهرةدكتور عظام فى القاهرة
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