Published on: 2025-06-15 | Written by: Dr. Ahmed Mujahid consultant in IVF laparoscopic surgery obstetrics
What’s the difference between ICSI and IUI? And which is more suitable for our case?
Dr. Ahmed Megahed, consultant in obstetrics, gynecology, and assisted reproduction, explains the fundamental differences between these two procedures, when each is recommended, and what success rates to expect.
IUI is a simple procedure in which a prepared sperm sample is injected directly into the uterus during the ovulation period. The goal is to bring the sperm closer to the egg and increase the chances of natural fertilization.
Non-surgical and quick procedure
Done in-clinic in just minutes
No anesthesia required
Lower cost compared to ICSI
Suitable for mild infertility cases
Unexplained infertility
Mild issues with sperm motility or count
Irregular ovulation with good response to medication
Minor cervical factor issues
Young couples under 35
ICSI is an advanced form of IVF (in vitro fertilization), where eggs are retrieved from the woman, and each egg is injected with a single sperm in a lab, followed by embryo transfer into the uterus.
Higher success rates than IUI
Suitable for complex or severe infertility cases
Can be combined with genetic embryo screening
Allows freezing of embryos for future cycles
Offers a real chance at pregnancy in previously impossible cases
Blocked fallopian tubes
Severe male factor infertility (low count, motility, or morphology)
Repeated IUI failure
Long-term unexplained infertility
Poor ovarian response or ovulation disorders
Advanced maternal age (above 35)
Factor | IUI (Intrauterine Insemination) | ICSI (Intracytoplasmic Sperm Injection) |
---|---|---|
Fertilization location | Inside the woman’s body | In the lab (outside the body) |
Medical intervention | Simple | Complex (involves anesthesia and retrieval) |
Cost | Relatively low | Higher due to lab procedures and technology |
Success rates | Around 10–20% | 40–60% depending on case and age |
Recommended attempts | Up to 3 cycles | Case-specific, often fewer cycles |
Complexity level | Low | High, requires specialized facilities |
“Choosing between IUI and ICSI isn’t about preference—it’s about precision. The best choice is made through thorough evaluation, understanding the root cause of infertility, and assessing the couple’s response to treatment,”
says Dr. Ahmed Megahed, adding that close monitoring and good timing significantly improve success rates.