Published on: 2025-06-18 | Written by: Dr. Shimaa El-Sayed, Senior Consultant of General Internal Medicine and Kidney Diseases
Loss of appetite and sudden weight loss may seem like temporary issues caused by stress or mood swings, but often, they are symptoms of a serious internal condition that requires medical attention. Dr. Shaimaa El-Sayed, Consultant of Internal Medicine and Kidney Diseases, explains the key causes, diagnostic methods, and treatment options.
Loss of appetite refers to a decreased desire to eat, while weight loss indicates unintended reduction in body mass over a short period.
Dr. Shaimaa El-Sayed emphasizes that losing more than 5% of body weight within six months without clear cause is abnormal and requires medical evaluation.
Digestive disorders such as ulcers, gastritis, or malabsorption
Chronic liver diseases affecting metabolism
Chronic kidney diseases, especially kidney failure
Thyroid dysfunction, like hyperthyroidism
Chronic infections such as tuberculosis or hepatitis
Cancers, which must always be ruled out
Psychological factors, including anxiety and depression
Dr. Shaimaa El-Sayed advises correlating other symptoms like fatigue, bloating, or abdominal pain for accurate diagnosis.
Complete blood tests (CBC, liver and kidney functions, thyroid tests)
Stool and urine analysis
Ultrasound or CT scan if needed
Nutritional evaluation and BMI calculation
Dr. Shaimaa El-Sayed recommends early testing if symptoms persist.
Treating the root cause once identified
Customized dietary plans with a nutritionist
Nutritional supplements, if necessary
Regular follow-ups to monitor weight and test results
Dr. Shaimaa El-Sayed stresses the importance of early intervention, especially for patients with liver or kidney conditions.
Appetite loss lasting more than two weeks
Unexplained weight loss
Accompanying symptoms like vomiting, diarrhea, or fatigue
Personal or family history of liver, kidney, or thyroid diseases
Book a consultation with Dr. Shaimaa El-Sayed to identify the cause and start the appropriate treatment.