Cortisol analysis for animals early detection of a serious condition

Have you noticed sudden changes in your pet’s behavior?
Is your furry friend experiencing hair loss, fatigue, or appetite issues without a clear reason? These could be signs of an imbalance in cortisol, one of the body’s key hormones responsible for stress response and essential metabolic functions.In this article from Daleely Medical, we’ll guide you through everything you need to know about the Cortisol Test for animals—when it's needed, how it's performed, how it's linked to conditions like Cushing’s and Addison’s disease, and expert tips to ensure accurate results and reliable diagnosis.

What Is Cortisol?

Cortisol is a hormone produced by the adrenal glands (located above the kidneys) in response to stress or pressure. It plays a vital role in:

Regulating blood pressure
Controlling blood sugar levels
Managing the body’s inflammatory response
Supporting metabolism and weight control
Strengthening the immune system

What Is the Cortisol Test for Animals?

The Cortisol Test is a blood or urine test used to measure cortisol levels in an animal's body. It helps diagnose disorders related to adrenal gland dysfunction, such as:

Cushing’s Disease:
Excessive production of cortisol.
Addison’s Disease:
Insufficient production of cortisol.

When Is the Cortisol Test Recommended for Pets?

Veterinarians usually recommend cortisol testing when symptoms suggest adrenal imbalance. These include:

Symptoms of High Cortisol (Cushing’s)	Symptoms of Low Cortisol (Addison’s)
Excessive drinking and urination	General weakness and lethargy
Increased appetite and abdominal obesity	Loss of appetite and weight loss
Hair loss or thinning coat	Vomiting and diarrhea
Bloated or swollen belly	Sudden collapse or shock
Muscle weakness	Slow heart rate

Types of Cortisol Tests in Veterinary Medicine

1. Baseline Cortisol Test

Measures cortisol at a specific point in time.
Not sufficient on its own for a definitive diagnosis.

2. ACTH Stimulation Test

The animal is injected with a hormone (ACTH) that stimulates cortisol production.
Cortisol levels are measured before and after.
Helps diagnose Cushing’s or Addison’s disease.

3. Low-Dose Dexamethasone Suppression Test (LDDST)

Dexamethasone (a corticosteroid) is administered.
The body’s cortisol response is measured.
Used to confirm Cushing’s and determine whether it originates from the adrenal glands or the pituitary gland.

How Is the Cortisol Test Performed?

A blood sample (or occasionally a urine sample) is collected.
The animal may need to fast or rest before testing.
Testing is usually done in the morning when cortisol levels are more stable.
In some cases, follow-up tests are done after giving stimulating or suppressive medications.

Interpreting Cortisol Test Results

Result	Possible Interpretation
High Cortisol Level	Cushing’s disease – Severe stress – Cortisone use
Low Cortisol Level	Addison’s disease – Adrenal gland failure

Is the Cortisol Test Painful or Risky for Animals?

No. It’s a simple blood draw and is generally safe.
In some cases, monitoring may be needed after administering hormones.
Always have the test performed at a licensed and experienced veterinary clinic.

Do All Pets Need a Cortisol Test?

Not all animals require this test. It is recommended in cases where there is:

Suspected adrenal gland dysfunction
Unexplained behavioral or physical changes
Abnormal response to medications
Chronic skin conditions unresponsive to treatment

Cortisol Test Cost for Animals

The cost depends on the test type and the veterinary clinic. Approximate prices:

Baseline Cortisol Test: EGP 500 – 1000
ACTH or LDDST Test: EGP 2000 – 3000

Other Tests That May Be Ordered Alongside the Cortisol Test

To aid in diagnosis, your vet may also request:

Complete Blood Count (CBC)
Blood Chemistry Panel
Kidney and liver function tests
Urinalysis

Tips Before Conducting a Cortisol Test

Don’t stop any medications unless advised by your vet.
Ensure your pet is calm and rested before testing.
Provide a full history of symptoms and onset dates.
Always follow up with a vet experienced in veterinary endocrinology.

✅ Conclusion

The Cortisol Test for animals is a valuable diagnostic tool for detecting adrenal gland disorders like Cushing’s and Addison’s disease. If you notice unusual changes in your pet’s energy, appetite, or coat condition, don’t delay—speak with your vet and run the necessary tests.