

Do you suffer from constant fatigue, poor concentration, tingling in your limbs, or mood swings?The cause may be a deficiency in one of the essential B-complex vitamins, such as B1 (Thiamine), B6 (Pyridoxine), or B9 (Folate). These vitamins play a vital role in converting food into energy, supporting the nervous system, and boosting overall body functions.
In this article from Dalili Medical, we take you on a simplified scientific journey through the importance of these vitamins, the symptoms of their deficiency, their natural sources, and related medical tests.
Function:
Converts carbohydrates into energy
Supports the heart, brain, and nervous system
Deficiency symptoms:
Constant fatigue
Loss of appetite
Muscle weakness
Memory or concentration problems
Peripheral neuropathy (tingling or numbness in hands/feet)
In severe cases: Beriberi or Wernicke’s encephalopathy
Natural sources:
Whole grains
Liver and other meats
Nuts
Legumes
Yeast
Function:
Involved in over 100 enzymatic reactions
Supports neurotransmitter production (serotonin, dopamine)
Boosts immune function
Helps produce hemoglobin
Regulates mood and sleep
Deficiency symptoms:
Mood changes or depression
Numbness or tingling in hands/feet
Weakened immunity
Muscle cramps
Mouth or tongue sores
Skin issues (rash, cracking)
Natural sources:
Bananas
Potatoes
Poultry
Fish
Fortified cereals
Spinach and broccoli
Function:
Vital for DNA synthesis
Crucial for healthy cell division and growth
Prevents neural tube defects during pregnancy
Supports red blood cell production
Aids brain and heart health
Deficiency symptoms:
Anemia
Pale skin
Memory or focus issues
Irritability or depression
Mouth ulcers
In pregnancy: Neural tube defects in the fetus
Natural sources:
Leafy greens (e.g., spinach)
Lentils and beans
Citrus fruits
Fortified whole grains
Liver and eggs
Which tests are used?
Vitamin B1 (Thiamine) test
Vitamin B6 (Pyridoxine) test
Folate (Vitamin B9) test
These tests are commonly ordered in cases of fatigue, neuropathy, or unexplained anemia.
Do I need to fast before the test?
Usually no, but follow your doctor’s or lab’s instructions.
B1: Converts glucose into energy for nerve cells
B6: Produces serotonin and dopamine — low levels may cause depression
B9: Supports brain cell regeneration and mood stabilization
Poor diet or strict vegan diets
Excessive alcohol intake
Pregnancy
Malabsorption (e.g., Celiac disease, Crohn’s disease)
Certain medications (e.g., metformin, antacids, diuretics)
Yes, they are available as:
Individual tablets (B1, B6, B9)
B-Complex combinations
Intramuscular injections in severe deficiencies
Always consult your doctor before starting any supplements.
Q: Can a lack of Vitamin B6 cause depression?
Yes. B6 is needed for serotonin production — a key mood-regulating neurotransmitter.
Q: Is folic acid important before pregnancy?
Absolutely. Taking folic acid before and during early pregnancy prevents neural tube defects in the baby.
Q: How do I know if I’m deficient in B1?
If you experience chronic fatigue, poor appetite, and tingling in your extremities, a thiamine test may be recommended.
Q: Can I take B1, B6, and B9 together?
Yes, and they are often more effective when taken as a B-Complex supplement.
Vitamins B1, B6, and B9 (Folate) are essential nutrients that support your brain, nerves, energy levels, and overall health. Deficiencies can lead to a range of physical and mental symptoms.
✅ Detecting low levels early and making dietary or medical adjustments can significantly improve your quality of life.