17Hydroxyprogesterone analysis is an essential test for diagnosing

Has your doctor recommended a 17-Hydroxyprogesterone (17-OHP) test?The name may sound complex, but this test plays a crucial role in diagnosing certain hormonal disorders, particularly adrenal insufficiency or Congenital Adrenal Hyperplasia (CAH).In this article from Dalili Medical, we provide a comprehensive guide to help you understand this test:What is it? Why is it ordered? How is it performed? And what do the results mean?

 What is the 17-Hydroxyprogesterone (17-OHP) Test?

The 17-OHP test is a blood test used to measure the level of 17-hydroxyprogesterone, a hormone produced by the adrenal glands (located above the kidneys).
This hormone is a precursor in the production of other vital hormones such as cortisol and androgens (male sex hormones).

An elevated level of 17-OHP in the blood may indicate a dysfunction in the adrenal glands, most commonly:

• Congenital Adrenal Hyperplasia (CAH)

• 21-Hydroxylase enzyme deficiency

 When is the 17-OHP Test Ordered?

Doctors may request this test in the following situations:

In Children:

• Signs of early puberty

• Ambiguous genitalia in newborns (either male or female)

• Recurrent low blood sugar (hypoglycemia) without a clear cause

In Women:

• Irregular menstrual cycles

• Excess hair growth on the face or body (hirsutism)

• Severe acne

• Infertility or difficulty getting pregnant

In Men:

• Low fertility

• Testosterone imbalances

 How is the 17-OHP Test Performed?

• A simple blood sample is drawn from a vein.

• The test is typically done early in the morning, when hormone levels are most accurate.

• In some cases, fasting may be required.

• In newborns, the test is often part of newborn screening and is performed using a small blood sample from the heel.

 Normal 17-OHP Levels

Reference ranges can vary by age, sex, and lab, but in general:

• Newborns: Slightly elevated levels are common in the first few days of life.

• Children and adults: Usually less than 200 ng/dL

• Women (mid-cycle): Often below 100–150 ng/dL

❗ What Do the Results Mean?

✅ Normal Level:

• Indicates normal adrenal function

• No signs of CAH or hormonal imbalance

❗ Elevated 17-OHP:

Could suggest one of the following:

• Congenital Adrenal Hyperplasia (CAH)

• 21-Hydroxylase deficiency

• Cortisol production disorders

• Adrenal or ovarian tumors (rare)

❌ Low 17-OHP:

Usually not concerning, but may be relevant in the context of other adrenal disorders.

⚖️ Comparison with Other Hormone Tests:

❓ Frequently Asked Questions About the 17-OHP Test

Do I need to fast before the test?

✅ Sometimes. Fasting may be recommended if other hormone tests are being done at the same time.

Does the menstrual cycle affect the test result?

Yes. It’s best to perform the test between day 3 and 5 of the menstrual cycle for more accurate interpretation.

Is this test used in children?

✅ Yes, it's a key screening test in newborns to detect CAH early.

Can elevated 17-OHP levels be treated?

Yes. Most cases are managed with hormone therapy, such as corticosteroids to regulate cortisol levels.

✍️ Summary

The 17-Hydroxyprogesterone test is an essential tool for diagnosing adrenal gland disorders, especially Congenital Adrenal Hyperplasia (CAH).
It helps detect hormonal imbalances responsible for early puberty, infertility, abnormal hair growth, or genital abnormalities in newborns.

If your doctor recommends this test, follow their instructions carefully and discuss the results with an endocrinologist for proper diagnosis and treatment planning.