Eye and Skin Analysis What are the necessary tests for skin and vision health

The eyes and skin are often the first parts of the body to show signs of internal imbalances—whether due to autoimmune conditions, vitamin deficiencies, or viral and bacterial infections.
In this Daleeli Medical guide, we introduce you to the most important medical tests related to skin and eye health.

First: Eye-Related Blood Tests

✅ 1. ANA (Antinuclear Antibodies)

Detects: Autoimmune diseases that may affect the eyes, such as lupus or Sjögren’s syndrome.

When is it needed?

• Severe dryness in the eyes

• Recurrent eye inflammation without a clear cause

• Chronic eye pain or redness

✅ 2. HLA-B27

Detects: Genetic predisposition to chronic inflammatory conditions such as uveitis or ankylosing spondylitis.

Recommended when:

• Frequent episodes of eye inflammation

• Lower back pain accompanied by vision issues

✅ 3. ACE (Angiotensin-Converting Enzyme)

Helps diagnose: Sarcoidosis – an autoimmune condition that can affect both the lungs and eyes.

Requested when:

• Persistent eye inflammation or nodules with no clear cause

• Respiratory problems associated with vision issues

✅ 4. CRP – ESR

Purpose: General markers of chronic inflammation in the body.

These are commonly used to monitor inflammatory activity in conditions such as vasculitis or rheumatoid arthritis, which may impact the eyes.

Second: Skin-Related Blood Tests

✅ 1. Zinc

Zinc deficiency may lead to:

• Delayed wound healing

• Chronic skin inflammation

• Hair loss

It is useful in diagnosing chronic eczema or unexplained skin rashes.

✅ 2. Vitamin D

Deficiency symptoms:

• Dry or flaky skin

• Skin rashes

• Weakened skin immunity

✅ 3. Vitamin A

Essential for both skin and vision health.

Deficiency signs include:

• Dry skin and eyes

• Night blindness or poor night vision

✅ 4. IgE – Allergy Panel

Detects: Skin allergies or inflammatory skin conditions caused by food, environmental triggers, or contact allergens.

When is it needed?

• Recurrent eczema

• Chronic itching

• Seasonal or unexplained skin rashes

✅ 5. ANA – Anti-dsDNA – ENA Panel

A group of autoimmune tests used to diagnose chronic inflammatory skin conditions, including:

• Systemic Lupus Erythematosus (Lupus)

• Scleroderma (systemic sclerosis)

• Dermatomyositis (inflammatory muscle and skin disease)

✅ 6. Skin Biopsy + Immunofluorescence

These are advanced dermatological tests used to diagnose chronic or rare skin diseases such as psoriasis, bullous pemphigoid, or pemphigus vulgaris.

The procedure involves taking a small skin sample for microscopic and immunological analysis.

When Should You Consider These Tests?

You may need skin and eye-related blood tests if you experience:

• Recurrent skin inflammation or chronic rashes

• Persistent itching or unexplained skin allergies

• Severe dryness in the eyes or vision changes

• Unusual skin discoloration, spots, or non-healing ulcers

• A known autoimmune disease affecting the skin or eyes

✅ Conclusion

Skin and eye-related blood tests are far more than cosmetic checkups — they are powerful diagnostic tools that reflect your body's internal and immune health.
Early detection of imbalances through these tests can help prevent serious complications such as vision loss or chronic skin damage.